Thomas Lab
Chemical Biology and Peptide Design

Publications

2019 – present
16.

"Guiding biomolecular interactions in cells using de novo protein-protein interfaces"

A. J. Smith, F. Thomas, D. Shoemark, D. N. Woolfson, N. J. Savery*, ACS Synth. Biol. 2019, 8, 1284–1293.
15.

"De novo designed α-helical coiled-coil peptides as scaffolds for chemical reactions"

W. M. Rink, F. Thomas*, Chem. Eur. J. 2019, 25, 1665–1677.
2018
14.

"Decoration of coiled-coil peptides with N-cysteine peptide thioesters as cyclic peptide precursors using CuAAC click reaction"

W. M. Rink, F. Thomas*, Org. Lett. 2018, 20, 7493–7497.
13.

"De novo designed α-helical barrels as receptors for small molecules"

F. Thomas, W. M. Dawson, E. J. M. Lang, A. J. Burton, G. J. Bartlett, G. G. Rhys, A. J. Mulholland, D. N. Woolfson*, ACS Synth. Biol. 2018, 7, 1808–1816.
12.

"Kinetic Studies on Strand Displacement in de novo Designed Parallel Heterodimeric Coiled Coils"

M. C. Groth, W. M. Rink, N. F. Meyer, F. Thomas*, Chem. Sci. 2018, 9, 4308–4316.
11.

"Carbon Nanotubes Encapsulated in Coiled-Coil Peptide Barrels"

F. A. Mann, J. Horlebein, N. F. Meyer, D. Meyer, F. Thomas*, S. Kruss*, Chem. Eur. J. 2018, 24, 12241–12245. Cover feature
2012 – 2017
10.

"Conformational Dynamics of Asparagine at Coiled-Coil Interfaces"

F. Thomas*, A. Niitsu, A. Oregioni, G. J. Bartlett, D. N. Woolfson*, Biochemistry 2017, 56, 6544–6554.
9.

"Controlling the Assembly of Coiled-Coil Peptide Nanotubes"

F. Thomas, N. C. Burgess, A. R. Thomson, D. N. Woolfson*, Angew. Chem. 2016, 128, 999–1003, Angew. Chem. Int. Ed. 2016, 55, 987–991; (selected as very important paper).
8.

"Modular Design of Self-assembling Peptide-based Nanotubes"

N. C. Burgess, T. H. Sharp, F. Thomas, C. W. Wood, A. R. Thomson, N. Zaccai, R. L. Brady, L. C. Serpell, D. N. Woolfson*, J. Am. Chem. Soc. 2015, 137, 10554–10562; (joint co-authorship).
7.

"Accessibility, Reactivity and Selectivity of Side Chains within a Channel of de novo Peptide Assembly"

A. J. Burton, F. Thomas, C. Agnew, K. L. Hudson, S. E. Halford, R. L. Brady, D. N. Woolfson*, J. Am. Chem. Soc. 2013, 135, 12524–12527.
6.

"A Set of de novo Designed Parallel Heterodimeric Coiled Coils with Quantified Dissociation Constants in the Micromolar to Sub-nanomolar Regime"

F. Thomas, A. L. Boyle, A. J. Burton, D. N. Woolfson*, J. Am. Chem. Soc. 2013, 135, 5161–5166.
5.

"Fmoc-based peptide thioester synthesis with self-purifying effect: heading to native chemical ligation in parallel formats"

F. Thomas*, J. Pep. Sci. 2013, 19, 141–147.

2007 – 2011
4.

"9-Fluorenylmethoxycarbonyl-Based Solid-Phase Synthesis of Peptide α-Thioesters"

F. Mende, O. Seitz*, Angew. Chem. 2011, 123, 1266-1274; Angew. Chem. Int. Ed. 2011, 50, 1232–1240.
3.

"Automated Fmoc-Based Solid-Phase Synthesis of Peptide Thioesters with Self-Purification Effect and Application in the Construction of Immobilized SH3-Domains"

F. Mende, M. Beisswenger, O. Seitz*, J. Am. Chem. Soc. 2010, 132, 11110–11118.
2.

"Chemical Control of Biomolecular Interaction Modules"

F. Altenbrunn, T. N. Grossmann, C. Haase, F. Mende, L. Röglin, S. Thurley and O. Seitz*, Pure Appl. Chem. 2009, 81, 2, 273–284.
1.

"Solid-Phase Synthesis of Peptide Thioesters with Self-Purification"

F. Mende, O. Seitz*, Angew. Chem. 2007, 119, 4661-4465; Angew. Chem., Int. Ed. 2007, 46, 4577–4580.
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